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Study of mice with gene-targeted alterations of the PrP gene
Reference
BBS/E/I/00000609
Principal Investigator / Supervisor
Professor Jean Manson
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
167,463
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
30/04/1999
Duration
25 months
Abstract
To use gene targeting in embryonic stem cells to produce new mouse strains with specific alterations to their endogenous prion protein (PrP) genes. Mice with mutations found in Gerstmann-Straussler- Scheinker Syndrome and Creutzfeldt- Jacob Disease will be studied for the development of spontaneous neurodegenerative disease and for susceptibility to scrapie. Mice with PrP codon 108 and 189 changes will be used to resolve the uncertainty over the equivalence of the PrP and scrapie incubation time (Sinc) loci. Mice with truncated forms of PrP will be used to investigate the relationship between PrP protein structure and ability to support replication of the scrapie agent.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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