Award details

Molecular pathogenesis of Marek's disease

Reference	BBS/E/I/00000380
Principal Investigator / Supervisor	Professor Venugopal Nair
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	371,110
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/08/1998
Duration	17 months

Abstract

Although the pathology of Marek's disease is well understood, the molecular events in oncogenesis are unclear. There has been a steady increase in the virulence of MDV in the last 30 years. The determinants of this increased virulence are also not properly understood. Studies in different laboratories have shown the role of different viral genes in the pathogenesis of MD. The aim of the present project is to examine the functions of the viral genes in cytolytic disease and oncogenesis. Increasing evidence suggests a critical role for cell cycle regulatory proteins in tumourigenesis and several DNA viruses, including some of the lymphotrophic viruses, target these proteins to induce S- phase entry and cell proliferation. Very little work has been done on the role of cell cycle deregulation in viral and oncogenesis in birds. This project will show the role of MDV genes in cell cycle regulation.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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