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Determinants of microbe-host responses in the gut across life

Reference	BBS/E/F/000PR10353
Principal Investigator / Supervisor	Professor Lindsay Jennifer Hall
Co-Investigators / Co-Supervisors	Dr Evelien Adriaenssens, Professor Laurence Ashley Blackshaw, Professor Simon Carding, Dr Falk Hildebrand, Professor Nathalie Juge, Professor Stella Knight, Dr Tamas Korcsmaros, Professor Arjan Narbad, Professor Martin Warren, Professor Tom Wileman
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	6,486,003
Status	Current
Type	Institute Project
Start date	01/04/2018
End date	31/03/2023
Duration	47 months

Abstract

To probe specific mechanistic aspects of the gut microbiome's positive influence on health throughout life, we have developed a systems-level experimental approach. We will use innovative in vivo, in vitro, and in silico tools/models in tandem with a key longitudinal cohort (pregnancy and early life) to define and refine novel intervention strategies that will promote gut health. Our multi-disciplinary research theme managed by QIB and university research leaders, maps to three objectives. These objectives will determine how microbes (bacterial, viral, fungal) establish and maintain a balanced community that modulates host homeostatic cross-talk within the gut. This theme involves a 250-particpant longitudinal population study of pregnancy mothers and their infants, up to 2 years of age. Theme 1 focusses on the gut during the very first stages of life, and in the elderly, and will seek to unravel: (i) how pioneer/keystone microbial species facilitate healthy development (ii) which microbial mediators modulate microbe-microbe and microbe-host cross-talk and (iii) bi-directional immune system-microbiota interactions within the gut. Theme 1 Outputs • identification of critical pre- and post-natal periods for establishing a healthy intestinal microbiome and the contribution that host and environmental factors play • define molecular mediators of microbe-microbe and microbe-host crosstalk important in microbial ecology and establishing tolerance Our integrated plan of work will ultimately determine microbiome- and host-associated pathways that could represent key targets for lifestyle changes and therapies that reduce the incidence and burden of infectious, metabolic, and immune-mediated conditions.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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