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Effects of a mixed intervention v. Folic acid supplement on folate status and cardiovascular disease (CVD) risk factors in healthy adults

Reference	BBS/E/F/00051943
Principal Investigator / Supervisor	Mr Paul Finglas
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	102,536
Status	Completed
Type	Institute Project
Start date	01/01/2005
End date	31/07/2008
Duration	43 months

Abstract

This study is designed to assess whether increasing the consumption of natural food folates from a mixed diet is as effective as supplemental folic acid in raising folate status, reducing biomarkers of CVD risk, and improving vascular function. Randomised placebo-controlled parallel studies will be undertaken in two groups of individuals in Norwich (healthy individuals) and Sheffield (moderately elevated plasma cholesterol) with folate-rich foods, supplemental folic acid (both at 200mu-g/d) and placebo capsules. Folate status, biomarkers of CVD risk and vascular function will be measured before and following the intervention period of 16 weeks, together with possible confounders (vitamins B2 & B12 status, and MTHFR genotype). 7-Day weighed intakes and 24-h recalls will be used to measure habitual B-vitamin intake during baseline and intervention to determine changes in folate intake and compliance. Additionally, folate content of selected folate-rich foods will be determined for each volunteer. The results will aid the Agency in formulating public health policy related to improving folate status and reducing CVD risk.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	Diet and Health
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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