Award details

Mechanisms by which interfacial layers control lipolysis on digestion (LIPOGEST)

Reference	BBS/E/F/00043296
Principal Investigator / Supervisor	Professor Victor Morris
Co-Investigators / Co-Supervisors	Professor Peter Wilde
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	119,500
Status	Completed
Type	Institute Project
Start date	01/04/2008
End date	30/04/2010
Duration	25 months

Abstract

Obesity is a major health problem within the member states of the European Union and the levels of obesity are currently increasing, especially in children. There is a strong correlation that exists between dietary fat intake and obesity, which in turn contributes to increased incidences of cardiovascular disease, diabetes and some cancers. These related conditions have a hugely detrimental impact on the quality of life of the sufferers and create an increasing drain on national health care resources. In order to develop novel approaches for reducing dietary fat intake, we need to understand the fundamental processes underlying lipid digestion. Therefore a major aim of this proposal is to understand a key aspect controlling lipid digestion (lipolysis) at a fundamental level. To achieve this we will use a multidisciplinary approach, bringing together the following key skills and expertise: 1. Physiological expertise is required to define and develop accurate models of lipid digestion which are representative of the in-vivo situation. 2. Interfacial skills and expertise are required to characterise properties of the interface where a key stage of lipid hydrolysis occurs. 3. Atomic force microscopy (AFM) imaging of biological systems is a highly specialist field and is essential to accurately visualise and understand the structural changes occurring at interfaces that are thought to influence lipolysis. The aim is to understand how conditions experienced during digestion affect interfacial structure and how these structural changes influence lipolysis.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Diet and Health, Structural Biology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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