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An investigation into the Bioavailability of flavins from food and the modulating effect of age and MTHFR genotypes on absorption in vivo function
Reference
BBS/E/F/00041653
Principal Investigator / Supervisor
Mr Paul Finglas
Co-Investigators /
Co-Supervisors
Institution
Quadram Institute Bioscience
Department
Quadram Institute Bioscience Department
Funding type
Research
Value (£)
9,914
Status
Completed
Type
Institute Project
Start date
01/10/2003
End date
16/01/2007
Duration
40 months
Abstract
Recent national surveys in the UK have highlighted an increasing prevalence of biochemical ariboflavinosis but a discrepancy with estimated riboflavin intakes. This study aims to quantify riboflavin bioavailability from foods and develop a mathematical model of absorption, and to evaluate the modulating effects of common polymorphisms in genes encoding for riboflavin dependent enzymes on the relationship between dietary intake and functional riboflavin status in humans. The pharmacokinetics of riboflavin absorption from food will be studied in humans using stable isotope methodology. The modulating effects of relevant common polymorphisms on intake/function relationships will be carried out in a controlled randomized human intervention study.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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