Award details

Folate bioavailability and metabolism

Reference	BBS/E/F/00041040
Principal Investigator / Supervisor	Mr Paul Finglas
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	1,681,592
Status	Completed
Type	Institute Project
Start date	01/04/1999
End date	31/03/2005
Duration	72 months

Abstract

Task managers: indicated in parentheses. Research on organic micronutrients encompasses definition of key factors of food structure which determine nutrient release in the human stomach and small intestine (Annette Fillery-Travis), physiological and dietary factors effecting subsequent absorption and post-absorptive metabolism (Richard Faulks, special emphasis on carotenoids; Paul Finglas, special emphasis on folates), and mechanisms of action at the tissue, cell and molecular level (Ruan Elliott). Experimental approaches include a range of cell and cell-free model systems for predicting bioavailability and bioactivity, the development of stable isotope approaches (using intrinsic and extrinsic labelling) for quantifying absorption and characterising metabolism of micronutrients in human volunteers, and application of new molecular biology techniques to understanding mechanisms of response at the level of DNA. The project as a whole is driven by public health issues, in particular, the role of carotenoid and folate-rich diets in reducing the incidence, and risk, of age/gene-related disorders

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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