Award details

The function of genes and cellular phenotypes in animal systems

Reference	BBS/E/D/10002071
Principal Investigator / Supervisor	Dr Denis Headon
Co-Investigators / Co-Supervisors	Professor Cheryl Ashworth, Professor John Kenneth Baillie, Dr Adam Balic, Dr Thomas Burdon, Dr Michael Clinton, Dr Megan Davey, Professor Paul Digard, Dr Francesc Donadeu, Professor Ian Dunn, Dr Cristina Esteves, Professor Colin Farquharson, Professor Tom Freeman, Dr James Glover, Dr Anton Gossner, Dr Peter Hohenstein, Professor Jayne Hope, Professor Ross Houston, Professor Neil Mabbott, Dr Vicky MacRae, Dr Barry McColl, Miss Laura McCulloch, Dr Michael McGrew, Dr Gerry McLachlan, Dr Clare Pridans, Dr Joe Rainger, Mr N Rashdan, Professor Helen Sang, Dr Jacqueline Smith, Professor Kim Summers, Dr Christine Tait-Burkard, Professor Lonneke Vervelde, Dr Kellie Watson, Professor Christopher Whitelaw, Professor Thomas Wishart
Institution	University of Edinburgh
Department	The Roslin Institute
Funding type	Research
Value (£)	9,562,432
Status	Current
Type	Institute Project
Start date	01/04/2017
End date	31/03/2023
Duration	59 months

Abstract

The aim of this project is to understand how gene products (proteins and ncRNAs) determine the properties of cells, tissues, organs and whole animals.Initial evidence of a functional role for predicted elements will be based on evolutionary and selection constraints. Direct evidence of function will be inferred from naturally-occurring genetic variants, use of targeted CRISPR/Cas9 mutagenesis or using highthroughput cell-based reporter systems. Novel editing strategies will be developed and exploited, including for knock-outs, allele substitutions and reporter knock-ins. The function of selected genes and regulatory elements in cell differentiation, tissue patterning and homeostasis of a range of cell and tissue types will be studied using cell lines, primary cells, organoids, organ systems and whole animals. The project will also study cell, tissue and body phenotypes during development and how these change through life.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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