Award details

The Healthy and Degenerating Neuron

Reference	BBS/E/D/05241341
Principal Investigator / Supervisor	Professor Jean Manson
Co-Investigators / Co-Supervisors
Institution	University of Edinburgh
Department	The Roslin Institute
Funding type	Research
Value (£)	2,103,445
Status	Completed
Type	Institute Project
Start date	01/08/2008
End date	31/03/2012
Duration	44 months

Abstract

We aim to use our extensive experience in TSEs to characterise the healthy and degenerating neuron, establish how homeostasis is maintained, and identify specific defects that occur as the cell begins to age. We aim to use TSE models to study the early events and late events of neurodegeneration in the CNS. Understanding such mechanisms may be of significance in all neurodegenerative disease and identify potential strategies for intervention to block the neurodegenerative process. The objectives of this theme are: To determine the normal function of PrP. To define the mechanisms of neurodegeneration. To identify and quantify changes in CNS and FDC gene expression related to TSE disease progression. Identify and quantify similarities and differences in disease associated changes between scrapie susceptible and resistant sheep. To study cellular maintenance and homeostasis in the presence of misfolded protein. To examine mechanisms of neurogenesis and application to disease prevention.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Ageing, Animal Health, Neuroscience and Behaviour, TSEs (transmissible spongiform encephalopathies)
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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