Award details

Neuro-immune modelling

Reference	BBS/E/D/05241339
Principal Investigator / Supervisor	Professor Jean Manson
Co-Investigators / Co-Supervisors
Institution	University of Edinburgh
Department	The Roslin Institute
Funding type	Research
Value (£)	1,405,126
Status	Completed
Type	Institute Project
Start date	01/08/2008
End date	31/03/2012
Duration	44 months

Abstract

The spread of TSE infection within the body of an animal often starts with transport from the site of invasion to the lymphoreticular system (LRS) and then to the central nervous system (CNS). We wish to study this process to identify the important factors that affect host susceptibility and to define control points at which neuroinvasion might be arrested so that clinical disease does not occur. The objectives of this theme are: To determine the mechanisms of TSE agent delivery to the lymphoid system. To determine crucial sites of TSE agent accumulation and/or replication in lymphoid tissues. To determine the mechanisms of neuroinvasion (how TSE agents spread to peripheral nerves). To determine the role of macrophages in TSE pathogenesis. To determine the influence of host age on TSE agent neuroinvasion. To determine the influence of inflammation on TSE pathogenesis.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology, Neuroscience and Behaviour, TSEs (transmissible spongiform encephalopathies)
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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