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Protein misfolding in neurodegenerative disease
Reference
BBS/E/D/05241338
Principal Investigator / Supervisor
Professor Jean Manson
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
The Roslin Institute
Funding type
Research
Value (£)
1,057,714
Status
Completed
Type
Institute Project
Start date
01/08/2008
End date
31/03/2012
Duration
44 months
Abstract
We aim to investigate the mechanisms of protein misfolding that lead to neurodegenerative disorders, including defining how, why and when it may occur in vivo. The study of well defined model systems such as the TSEs are expected to identify mechanisms which will be common to other protein misfolding diseases. The objectives of this theme are: To define the detailed molecular mechanisms underpinning protein misfolding. To define the roles of amino acid changes in protein misfolding. To define the contribution of post-translational modifications to the misfolding process. To define the roles of misfolded isoforms of protein in the pathobiology of disease.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
Animal Health, Neuroscience and Behaviour, Structural Biology, TSEs (transmissible spongiform encephalopathies)
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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