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BBSRC DTA Studentship: MAP Kinases signals that regulate protein degradation

Reference	BBS/E/B/0000L992
Principal Investigator / Supervisor	Dr Simon Cook
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	114,122
Status	Completed
Type	Institute Project
Start date	01/10/2005
End date	30/09/2009
Duration	48 months

Abstract

The abundance of certain proteins within a cell is key to regulating its fate. For example, the normal division of a cell into two daughter cells is controlled by the cyclical accumulation of certain key cell cycle regulatory proteins. In many cases the expression of these proteins is regulated by changes in the activity of the gene encoding the protein. However, it is increasingly clear that certain signals can control the abundance of proteins themselves directly, either by promoting or inhibiting their destruction. This project will seek to understand how certain cell signalling pathways control protein destruction and relate to cell survival. The work is of a fundamental nature, but in the long term the results may be important to future efforts in understanding diseases such as cancer, autoimmunity and neurodegeneration.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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