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BBSRC DTA CASE Studentship: Development of Lentivirus-delivered RNAi to study the roles of PI3Ks in inflammatory responses of primary cells and in the murine bone marrow compartment
Reference
BBS/E/B/0000L986
Principal Investigator / Supervisor
Professor Len Stephens
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
225,189
Status
Completed
Type
Institute Project
Start date
01/05/2005
End date
30/09/2008
Duration
41 months
Abstract
The family of intracellular signalling enzymes called PI3Ks (phosphoinositide 3-kinases) are key components of the cell communication machinery; they are involved in a diverse range of cellular processes, from cell movement to cell division and play a critical role in immune defence. We will develop an approach to create mice with specific genetic modifications in their bone marrow and use this to understand the role of selected genes in the immune system.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
Immunology, Microbiology, Stem Cells
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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