BBSRC Portfolio Analyser
Award details
BBSRC Quota Studentship: Regulation of DUSP5 and DUSP6 expression in RAS and BRAF-dependent tumour cells
Reference
BBS/E/B/0000L953
Principal Investigator / Supervisor
Dr Simon Cook
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
12,923
Status
Completed
Type
Institute Project
Start date
01/10/2003
End date
30/09/2007
Duration
48 months
Abstract
KRAS and BRAF are human proto-oncogenes that are mutated in human tumours and lead to hyperactivation of the ERK1/2 signalling pathway. ERK1/2 are protein kinases that phosphorylate key substrates to promote gene expression, cell proliferation and cell survival. ERK1/2 are themselves activated by phosphorylation catalysed by a protein kinase called MEK1. ERK1/2 are inactivated by removal of these activating phosphates and this is catalysed by one of a number of phosphatases. Two of these phosphatases, called DUSP5 and DUSP6, are absolutely specific for ERK1/2 in cells. The expression of DUSP5 and DUSP6 can be increased in response to ERK1/2 activation as part of a self-regualting feedback mechanism. This project will investigate the degree to which this operates in human tumour cells which exhibit activation of the ERK1/2 pathway.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search