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BBSRC DTG studentship: How do cells adapt to loss of ERK1/2 signalling?
Reference
BBS/E/B/0000L742
Principal Investigator / Supervisor
Dr Simon Cook
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
95,765
Status
Completed
Type
Institute Project
Start date
01/10/2009
End date
30/09/2013
Duration
48 months
Abstract
From the moment of fertilisation onwards, cell division is subject to careful control throughout the lifetime of multicellular organisms, including man. Loss of this control can lead to developmental abnormalities and birth defects, whilst in later life de-regulated cell division can lead to cancer, cardiovascular disease and inflammatory disease. Cell division is coordinated by biochemical signal pathways inside cells; these pathways respond to environmental cues and instruct the cell to divide or not, depending on the circumstances. One such pathway involves a cascade of enzymes called the ERK1/2 pathway. This pathway plays a central role in the control of cell division and has emerged as an attractive target for new drugs, especially those directed against cancer. However it is still not fully clear how cells will respond long term to the inhibition or loss of ERK1/2 signalling and this is the goal off this project.
Summary
unavailable
Committee
Not funded via Committee
Research Topics
Pharmaceuticals, Stem Cells
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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