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BBSRC/CASE studentship: Determinants of tumour cell sensitivity to PI3K and TOR pathway inhibitors
Reference
BBS/E/B/0000L717
Principal Investigator / Supervisor
Dr Simon Cook
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
130,430
Status
Completed
Type
Institute Project
Start date
01/10/2007
End date
30/09/2011
Duration
48 months
Abstract
In comparison to normal cells, rapidly dividing tumour cells have greater metabolic demands and re-model their metabolic pathways accordingly to satisfy energy demands. In some cases the tumour cell may actually switch to devouring its own components to satisfy energy demand, a process known as autophagy. Many of the new drugs now entering clinical trials impinge on this autophagy pathway. In this project we aim to investigate how modifying the autophagy pathway influences the tumour cell response to novel chemotherapy drugs.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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