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PI3K and Vav-dependent regulation of Rac activation, reactive oxygen species production and phagocytosis by neutrophils

Reference	BBS/E/B/0000L110
Principal Investigator / Supervisor	Professor Len Stephens
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	136,149
Status	Completed
Type	Institute Project
Start date	09/04/2004
End date	08/04/2007
Duration	36 months

Abstract

Neutrophils are a type of white blood cell involved in the destruction of potentially pathogenic organisms. A key step in the process of destruction is the engulfment of the pathogen (phagocytosis) and its chemical breakdown. The chemical digestion process is triggered by local production of highly reactive chemicals. We aim to identify the molecules and mechanisms operating inside neutrophils leading to the formation of these highly reactive chemicals. This information will identify new potential targets for anti-inflammatory drugs, because in a number of chronic inflammatory diseases neutrophils become over-activated and begin to destroy healthy joint tissue.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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