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Regulation of the pro-apoptotic Bcl-2 protein Bim by MAPK pathways

Reference	BBS/E/B/0000L023
Principal Investigator / Supervisor	Dr Simon Cook
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	90,885
Status	Completed
Type	Institute Project
Start date	01/04/2003
End date	31/10/2004
Duration	19 months

Abstract

Apoptosis underpins the normal morphogenetic processes of metazoan development and serves to protect the organism from a variety of diseases including cancer and auto-immune syndromes. The ability of cells to survive and proliferate at low serum or cytokine concentrations is a hall mark of a variety of hyper-proliferative and immune/inflammatory syndromes. From a commercial standpoint apoptotic cell death may be a limiting factor in the production of biomass from large scale serum replacement tissue culture systems and may also limit the efficacy and/or spread of viral drug discovery systems. Consequently an understanding of the regulation of apoptosis will have an impact on fundamental biology, the healthcare sector and biology which underpins the allpications of cell culture. This project aims to identify the role MAPK pathways in regulating cell survival during factor withdrawal induced cell death and in particular the role of the MAPKs in regulating the expression and activity (by phosphorylation) of the pro-death protein Bim which may represent an interface or cross talk between cell death and cell survival signalling pathways.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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