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The role of Bcl-2 proteins in regulating metabolism in normal and tumour cells
Reference
BBS/E/B/0000H248
Principal Investigator / Supervisor
Dr Simon Cook
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
68,776
Status
Completed
Type
Institute Project
Start date
28/09/2009
End date
27/09/2012
Duration
36 months
Abstract
Tumour cells exhibit a number of properties that set them apart from normal cells. Understanding what makes a tumour cell different from a normal cell is important as it may allow us to identify new ways to selectively kill tumour cells. Tumour cells differ markedly from normal cells in the way they generate energy, being far more dependent upon the metabolism of glucose (a process known as glycolysis) than normal cells. We are interested in determining if this is an ‘Achilles heel’ by which we can attack tumour cells. If we disrupt glycolysis do tumour cells die? If so, how do they die? If not then, are they now more vulnerable to death in response to other drugs?
Summary
unavailable
Committee
Not funded via Committee
Research Topics
Pharmaceuticals
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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