BBSRC Portfolio Analyser
Award details
Role of ERK5 in cell transformation and P53 regulation
Reference
BBS/E/B/0000H242
Principal Investigator / Supervisor
Dr Simon Cook
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
80,888
Status
Completed
Type
Institute Project
Start date
01/04/2009
End date
31/03/2012
Duration
36 months
Abstract
The behaviour of all cells is controlled by a range of environmental factors and this is true during development in the embryo (responding to developmental signals), in the adult organism (responding to environmental changes) and in disease. Environmental changes trigger the activation of biochemical signal pathways inside the cell that act to coordinate the cellular response. These signal pathways are frequently mutated in diseases such as cancer and may represent attractive drug targets. One such signal pathway leads to the activation of an enzyme called ERK5. In this project we aim to understand how ERK5 controls processes such as cell division, cell survival and cell movement. In doing so we hope to better understand the normal function of ERK5 but also to determine if ERK5 is a good drug target in cancer.
Summary
unavailable
Committee
Not funded via Committee
Research Topics
Pharmaceuticals
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search