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Bim as a determinant of cell death in human colorectal cancer cells
Reference
BBS/E/B/0000H151
Principal Investigator / Supervisor
Dr Simon Cook
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
61,965
Status
Completed
Type
Institute Project
Start date
01/04/2005
End date
31/03/2008
Duration
36 months
Abstract
Cancer cells are characterised by their ability to grow and divide under conditions and in environments within the body in which normal cells would die. This process of cell death is termed 'apoptosis' and is the normal mechanism by which abnormal or unwanted cells are destroyed. Cancer cells have developed or evolved various strategies to evade this cell death mechanism. It is hoped that if we can understand both the mechanism of normal cell death and the mechanism by which cancer cells evade it then we may be able to design better strategies (drugs) for selectively killing cancer cells. The Bim gene is particularly important in killing normal cells and yet it is found at greatly reduced levels in tumour cells. We hope to understand how tumour cells neutralise the Bim gene.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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