Award details

Signalling pathway regulation of human and mouse cdx genes

Reference	BBS/E/B/0000C224
Principal Investigator / Supervisor	Dr Stephen Gaunt
Co-Investigators / Co-Supervisors	Dr Simon Cook
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	199,197
Status	Completed
Type	Institute Project
Start date	01/08/2006
End date	30/09/2008
Duration	26 months

Abstract

The three vertebrate cdx genes (human and mouse cdx1, 2 and 4) play important roles both in the patterning of embryos along the head-tail axis and in the origin and malignant progression of gut tumours in the adult. Little is currently known about how the cdx genes are regulated. Using cell culture systems we shall elucidate the extra- and intra-cellular signalling pathways that regulate these genes. The findings will shed light both on the origins of head-tail patterning in embryos, and also on molecular mechanisms for progression and inhibition of malignancy in human colorectal carcinomas.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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