Award details

Regulation of cell proliferation and differentiation by protein kinase signalling pathways

Reference	BBS/E/B/0000C199
Principal Investigator / Supervisor	Dr Simon Cook
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	2,477,907
Status	Completed
Type	Institute Project
Start date	01/04/2003
End date	31/03/2012
Duration	108 months

Abstract

Cells grow and divide by progressing through the cell cycle. The cell cycle consists of four phases: the synthesis phase (S); gap 1 (G1); mitosis (M); and gap 2 (G2). The ordered progression through these phases ensures that the genome is replicated exactly once per cell cycle and that the genomic replicates are segregated equally into two daughter cells. During the G1 phase the cells make the necessary preparations for replicating their DNA in S phase, whilst in G2 the cells prepare for segregation of replicated chromosomes into daughter cells during cell division, known as mitosis (M phase). Progression through G1 and into S is strictly controlled by the availability of external growth stimuli called growth factors. These growth factors activate signalling pathways inside the cell, such as the ERK and PI3K signal pathways, that act to promote the G1 to S phase transition. In contrast, certain stimuli outside of the cell tell the cell if the environment is not conducive to cell division; these include, indicators of poor metabolic state and cellular stresses that cause genomic damage. The last thing a cell wants to do is to replicate damaged DNA, or pass it on to its daughter cells. In this project we seek to understand the mechanisms by which metabolic cues (such as high cAMP levels) and stress stimuli, that activate the JNK and p38 signal pathways, integrate with the cell cycle machinery to inhibit cell cycle progression. The results should be of relevance to the healthcare and pharmaceutical sectors.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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