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Regulation of cell cycle progression by anti-proliferative signalling pathways

Reference	BBS/E/B/00001199
Principal Investigator / Supervisor	Dr Simon Cook
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	324,191
Status	Completed
Type	Institute Project
Start date	01/04/2003
End date	31/03/2006
Duration	36 months

Abstract

Cells grow and divide by progressing through the cell cycle. During the G1 phase the cells make the necessary preparations for replicating their DNA in S-phase, whilst in G2 the cells prepare for segregation of replicated chromosomes into daughter cells in mitosis (M phase). Progression through G1 and into S is strictly controlled by the availability of external growth stimuli called growth factors. These growth factors activate intracellular signalling pathways such as the ERK and PI3K signal pathways that act to promote the G1->S-phase transition. In contrast, certain extracellular stimuli tell the cell if the environment is not conducive to cell division; these include, indicators of poor metabolic state and cellular stresses that cause genomic damage. The last thing a cell wants to do is to replicate damaged DNA, or pass it on to its daughter cells. In this project we seek to understand the mechanisms by which metabolic cues (such as high cAMP levels) and stress stimuli, that activate the JNK and p38 signal pathways, integrate with the cell cycle machinery to inhibit cell cycle progression. The results should be of relevance to the healthcare and pharmaceutical sectors.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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