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PtdIns(3,4,5)P3 and superoxide formation
Reference
BBS/E/B/00001181
Principal Investigator / Supervisor
Professor Len Stephens
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
564,076
Status
Completed
Type
Institute Project
Start date
01/09/1999
End date
31/03/2005
Duration
67 months
Abstract
Superoxide ions are an important tool in human defenses against a wide variety of pathogens. They are released upon appropriate stimulation by specialised cells like neutrophils to kill invading bacteria and fungi. People who have genetic problems in this system have very severe problems with chronic bacterial and fungal infections. However, when this system goes wrong and becomes overactive, it can lead to chronic inflammatory conditions like arthritis. We are studying the molecular mechanisms by which hormones and inflammatory stimulants activate superoxide formation.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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