Award details

PtdIns(3,4,5) P3 regulation of a novel Rho-family GAP protein

Reference	BBS/E/B/00001180
Principal Investigator / Supervisor	Professor Len Stephens
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	575,958
Status	Completed
Type	Institute Project
Start date	01/09/1999
End date	31/03/2005
Duration	67 months

Abstract

Rho-family proteins are key regulators of the dynamic protein scaffold inside cells. This scaffold is connected to the peripheral membrane of cells and sometimes via that to solid substratum. It is in constant flux, growing at specific points and disassembling at others. The shape of the scaffold determines the shape of the cell and movement or force generation relative to its surroundings. The Rho proteins can stimulate complex and in-ordinated changes in the scaffold such as creation of small flap-like structures from the edges of cells thought to be involved in directing migration of cells towards hormones. GAP proteins specifically inactivate Rho proteins and hence stop their effects on the cytoskeleton. We have discovered a new Rho GAP and are attempting to understand its function.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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