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Investigating the role of glycosylation in the TSE's
Reference
BBS/E/A/00001655
Principal Investigator / Supervisor
Professor Jean Manson
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
The Roslin Institute Department
Funding type
Research
Value (£)
112,832
Status
Completed
Type
Institute Project
Start date
01/04/2007
End date
31/03/2010
Duration
36 months
Abstract
The project objectives are to determine whether host PrP glycosylation influences the spread of infectivity from the periphery to the CNS and whether this is TSE strain dependent, to determine whether PrP glycosylation is important in the maintenance of TSE strain characteristics, to establish whether glycosylation processes are affected by TSE infection and to investigate the formation of plaques in PrP glycosylation-restricted mice.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
Animal Health, Neuroscience and Behaviour, TSEs (transmissible spongiform encephalopathies)
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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