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Elucidating the biosynthesis of d1 heme and its delivery to periplasmic cytochrome cd1 nitrite reductase
Reference
BBS/B/10323
Principal Investigator / Supervisor
Professor Stuart John Ferguson
Co-Investigators /
Co-Supervisors
Professor Martin Warren
Institution
University of Oxford
Department
Biochemistry
Funding type
Research
Value (£)
215,426
Status
Completed
Type
Research Grant
Start date
01/05/2004
End date
30/04/2007
Duration
36 months
Abstract
Heme d1 is the essential cofactor for cytochrome cd 1 nitrite reductase. This heme is an iron containing dioxoisobacteriochlorin whose synthesis and delivery to apo enzyme in the bacterial periplasm is catalysed by seven dedicated gene products which use uroporphyringen III as the precursor. A multi-disciplinary approach will be used to elucidate the enzymology of this remarkable biogenesis pathway along which the loss of propionic acid groups and their replacement by oxo groups is of particular interest.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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