Award details

The Manchester Centre for Integrative Systems Biology (MCISB)

Reference	BB/C008219/1
Principal Investigator / Supervisor	Professor Hans Westerhoff
Co-Investigators / Co-Supervisors	Dr Casey Bergman, Professor Andy Brass, Professor David Sidney Broomhead, Dr Martin Brown, Dr Philip Day, Professor Jeremy Paul Derrick, Professor Peter Fielden, Professor Sabine Flitsch, Professor David Foster, Professor Simon James Gaskell, Professor Carole Goble, Professor Nick Goddard, Professor Royston Goodacre, Professor Christopher Grant, Professor Simon Hubbard, Professor Dean Jackson, Professor John Keane, Professor Joshua Knowles, Professor Nicholas Lockyer, Professor Gerardus Hendricus Markx, Professor Ferda Mavituna, Professor John McCarthy, Professor Pedro Mendes, Professor Jason Micklefield, Dr Mark Muldoon, Professor Stephen Oliver, Professor Stefano Panzeri, Professor Norman Paton, Professor Graham Pavitt, Professor Paul Lode Albert Popelier, Professor Magnus Rattray, Dr Jonathan Shapiro, Dr Benjamin Stapley, Dr Lubomira Stateva, Professor Gillian Stephens, Professor Colin Stirling, Professor Nicholas Turner, Professor John Vickerman, Professor Hong Wang, Dr James Warwicker, Professor Simon Webb, Professor Hujun Yin, Professor Henggui Zhang
Institution	The University of Manchester
Department	Chemistry
Funding type	Research
Value (£)	6,311,964
Status	Completed
Type	Research Grant
Start date	01/10/2005
End date	30/09/2011
Duration	72 months

Abstract

Systems Biology seeks to understand complex systems in terms of the interactions between their component parts. Thus a car is understood in terms of what is connected to what(engine to gears to wheels, etc., and where the petrol goes), and how each subsystem contributes to the performance of the whole. It is necessary and desirable to take a similar approach to understanding how cells work. Since proteins are the main components in cells that do useful things, we wish to develop the necessary technology to purify these proteins in an efficient and automated manner. We shall then be in a position to develop methods to determine what other substances bind to or react with them and how tightly and fast. This determines how the system is constructed and how all the separate parts of it respond when conditions change. Although the way we intend to go about our business is effectively the same for all types of cell (or car or radio), we shall concentrate on baker's yeast as it is easy to work with and important in showing the principles of how cells behave. All of the data are to be stored in a special database, and we shall then be able to compare what happens in a mathematical model of the cells with what happens in the 'real' cells, and keep on adjusting the mathematical model accordingly. The purpose of this request for public money is to put in place, in a Centre devoted to this kind of work (The Manchester Interdisciplinary Biocentre), the techniques, people and instrumentation that will allow these very large-scale studies to proceed.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	Microbiology, Systems Biology, Technology and Methods Development
Research Priority	X – Research Priority information not available
Research Initiative	Integrative and Systems Biology (ISB) [2004-2005]
Funding Scheme	X – not Funded via a specific Funding Scheme

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