Award details

Comparisons of nutrient sensitivity of muscle protein turnover in young adults and wasted or well preserved elders

Reference	BB/X510697/1
Principal Investigator / Supervisor	Professor Michael Rennie
Co-Investigators / Co-Supervisors
Institution	University of Nottingham
Department	Graduate Entry Medical School
Funding type	Research
Value (£)	242,185
Status	Completed
Type	Research Grant
Start date	01/04/2004
End date	31/07/2005
Duration	16 months

Abstract

The protein needs of the elderly are controversial, some workers claiming a need for extra protein to best maintain muscle mass. Most work in this area has used nitrogen balance or isotopically determined amino acid plasma flux and oxidation but little work has examined the responses of muscle per se to altered availability of amino acids. It is however claimed that nutrient insensitivity exists in elderly muscle i.e. a diminished anabolic response to mixed meals or amino acids and carbohydrate mixtures. We aim to test this hypothesis by comparing dose and response between plasma amino acids and muscle protein turnover (and signalling elements such as p70 S6 kinase) in healthy young adults and well preserved or wasted elderly subjects.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

D18066 Comparisons of nutrient sensitivity of muscle protein turnover in young adults and wasted or well preserved elders

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