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Co-evolution of small molecule responsive riboswitches
Reference
BB/D005612/1
Principal Investigator / Supervisor
Professor Jason Micklefield
Co-Investigators /
Co-Supervisors
Dr Finbarr Hayes
,
Professor John McCarthy
Institution
The University of Manchester
Department
Chemistry
Funding type
Research
Value (£)
688,480
Status
Completed
Type
Research Grant
Start date
16/05/2006
End date
15/09/2010
Duration
52 months
Abstract
Small molecule modulators of gene expression, which offer rapid, temporal and spatial control of gene expression, would be tremendously valuable tools in biological and biomedical sciences. Indeed there are relatively few examples of small molecule-inducible expression systems that are available for general use. In addition, the ability to control differentially the expression of multiple genes simultaneously, using distinct small molecule inhibitors or inducers, remains extremely limited. In this project we aim to engineer new regulatory systems that function in prokaryotic and eukaryotic cells and respond in a rapid dose-dependent fashion to a wide range of small drug-like molecules. It is envisaged that the ability to control gene expression in response to a wide range of small molecule could lead to many profound applications in pharmaceutical target validation, gene therapy, bioremediation, biosensors, and plant biotechnology.
Summary
Small molecule modulators of gene expression, which offer rapid, temporal and spatial control of gene expression, would be tremendously valuable tools in biological and biomedical sciences. Indeed there are relatively few examples of small molecule-inducible expression systems that are available for general use. In addition, the ability to control differentially the expression of multiple genes simultaneously, using distinct small molecule inhibitors or inducers, remains extremely limited. In this project we aim to engineer new regulatory systems that function in prokaryotic and eukaryotic cells and respond in a rapid dose-dependent fashion to a wide range of small drug-like molecules. It is envisaged that the ability to control gene expression in response to a wide range of small molecule could lead to many profound applications in pharmaceutical target validation, gene therapy, bioremediation, biosensors, and plant biotechnology.
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
Industrial Biotechnology, Microbiology, Technology and Methods Development
Research Priority
X – Research Priority information not available
Research Initiative
Selective Chemical Intervention In Biological Systems (SCIBS) [2005]
Funding Scheme
X – not Funded via a specific Funding Scheme
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