Award details

High performance computing resources for structural biology and bioinformatics

Reference	BB/C511748/1
Principal Investigator / Supervisor	Professor Christine Orengo
Co-Investigators / Co-Supervisors	Dr Andrew Dingley, Professor Snezana Djordjevic, Dr Paul Driscoll, Professor David Jones, Professor John Ladbury, Professor Andrew Martin, Dr Sylvia Nagl, Professor Stephen Perkins, Professor Gabriel Waksman, Dr Mark Williams
Institution	University College London
Department	Structural Molecular Biology
Funding type	Research
Value (£)	124,320
Status	Completed
Type	Research Grant
Start date	01/01/2005
End date	31/12/2005
Duration	12 months

Abstract

The core computational resource requested here will support all the structural biology and bioinformatics research in the BSM Unit. The unit is devoted to understanding biological function from a structural perspective and the major themes of our research are signal transduction (both inside and outside the cell), molecular microbiology, including post-pathogen interactions, and the fundamental principles of protein structure, interaction, function and evolution. In signal transduction, we aim to unravel the mechanism of transmembrane receptor activation, particularly in T cell receptor and growth factor tyrosine kinase receptor pathways. In molecular microbiology, research is directed to understanding functional multi-protein systems and to potential targets for future antibiotics. In unravelling the biophysical basis of protein function, we are increasingly using computational approaches to interpret our experimental data on, and to predict properties or, protein-protein, protein-DNA and protein-ligand complexes. In bioinformatics, our research will focus on the relationship between structure and function and using the structural data to help interpret genome information. Also in exploiting our protein family and function resources in the datamining of functional genomics data. This will help us to understand the evolution of protein families, pathways and their functions.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Research Equipment Initiative 2004 (RE4) [2004]
Funding Scheme	X – not Funded via a specific Funding Scheme

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