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The molecular enzymology of nitric oxide reductase: cellular saviour and global bandit!

Reference	BB/C007719/1
Principal Investigator / Supervisor	Dr Nicholas James Watmough
Co-Investigators / Co-Supervisors	Professor Julea Butt, Dr Myles Cheesman, Dr Sarah Field, Professor David Richardson
Institution	University of East Anglia
Department	Biological Sciences
Funding type	Research
Value (£)	221,432
Status	Completed
Type	Research Grant
Start date	01/09/2005
End date	31/08/2009
Duration	48 months

Abstract

Nitric oxide reductase (NOR) is a bacterial enzyme that catalyses the reductive coupling of two molecules of NO to form N2O. We will use a range of contemporary spectroscopies, electrochemistry and rapid reaction kinetics to discover how the enzyme binds the two NO molecules at its active site to promote formation of an N-N bond, and what chemical intermediates are involved during a single turnover. Our experiments will provide new information as to how NOR controls the temporal and spatial arrival of substrate electrons and protons at the active site to allow productive reaction, rather than formation of any inhibitory species eg. Fe(II)-NO.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	Industrial Biotechnology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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