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Three-dimensional structure of cyclase-associated protein (CAP): a protein involved in cell development and endocytosis
Reference
B19520
Principal Investigator / Supervisor
Professor Andreas Hofmann
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Inst of Cell and Molecular Biology
Funding type
Research
Value (£)
181,124
Status
Completed
Type
Research Grant
Start date
01/09/2003
End date
31/08/2006
Duration
36 months
Abstract
The adenylyl cyclase-associated protein from Dictyostelium discoideum is required for Ras-dependent activation of the cyclase. At the same time, due to its actin-binding activity, CAP participates in reorganisation, and integrity of the cytoskeleton, which also involves the protein in vesicle trafficking and endocytosis. CAP, therefore, links the cAMP signalling pathway to changes in the cytoskeleton and knowledge of its molecular mechanism will enhance our understanding of cell development. We propose to produce recombinant CAP in order to determine its three-dimensional crystal structure. Structure-function relationships will be established to characterise CAP interactions with its target proteins (Ras, actin) on the molecular level.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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