Award details

Design synthesis and biological evaluation of novel tubulin ligands

Reference	B18009
Principal Investigator / Supervisor	Professor Nicholas Tomkinson
Co-Investigators / Co-Supervisors
Institution	Cardiff University
Department	Chemistry
Funding type	Research
Value (£)	119,072
Status	Completed
Type	Research Grant
Start date	14/05/2003
End date	13/05/2005
Duration	24 months

Abstract

Tubulin is an important target for cancer chemotherapy. Drugs that bind to the protein can block the dynamic equilibrium that exists between tubulin dimers and microtubules, resulting in cell death. Colchicine is an antimitotic agent known to inhibit tubulin polymerisation. The project will try to understand the detailed interactions involved between tubulin and bioactive ligands that bind to the colchicine binding site. The study of this protein:ligand interaction should allow the development of a molecular model for the colchicine-binding site followed by the design and biological evaluation of novel agents capable of binding specifically to tubulin with reduced side effects. (Joint with grant 18017).

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

B18017 Design synthesis and biological evaulation of novel tubulin ligands

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