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NMR investigations of the solution structure and dynamics of the MS2 bacteriophage translational operator coat protein and their complexes
Reference
B16723
Principal Investigator / Supervisor
Professor Peter Stockley
Co-Investigators /
Co-Supervisors
Professor Steve Homans
,
Professor Nicola Jane Stonehouse
Institution
University of Leeds
Department
Inst of Molecular & Cellular Biology
Funding type
Research
Value (£)
207,456
Status
Completed
Type
Research Grant
Start date
11/11/2002
End date
11/11/2005
Duration
36 months
Abstract
We will use NMR spectroscopy to investigate the solution structures and dynamics of the RNA bacteriophage MS2 translational operator RNA, a non-assembling coat protein dimer and their complexes. Dynamic properties of such systems are poorly understood and yet are vital for understanding the basis of intermolecular complex formation. Microcalorimetry will be used in concert with the structural studies in order to obtain direct of estimates of DeltaCp and other thermodynamic parameters.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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