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Probing membrane transport protein-ligand complexes by use of residual dipolar and quadrupolar couplings
Reference
B12993
Principal Investigator / Supervisor
Professor Steve Homans
Co-Investigators /
Co-Supervisors
Professor Peter Henderson
,
Dr R Herbert
Institution
University of Leeds
Department
Inst of Molecular & Cellular Biology
Funding type
Research
Value (£)
235,276
Status
Completed
Type
Research Grant
Start date
01/04/2000
End date
01/07/2003
Duration
39 months
Abstract
The structure determination of integral membrane protein-ligand complexes remains one of the great challenges of contemporary structural biology. Conventional solution NMR methods will generally fail in this context due to the large molecular sizes of the complexes. Here, a novel NMR approach is described based on residual dipolar and quadrupolar couplings in dilute liquid crystalline media that should enable the study of ligand binding to membrane transport proteins in a lipid bilayer environment. To the best of our knowledge these studies will represent an unique development in the UK.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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