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Biomolecular redox recognition of platinum anticancer agents: novel targeting strategies
Reference
B12897
Principal Investigator / Supervisor
Professor Peter Sadler
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Sch of Chemistry
Funding type
Research
Value (£)
187,247
Status
Completed
Type
Research Grant
Start date
01/03/2000
End date
31/01/2004
Duration
47 months
Abstract
New roles of sulphur donor ligands in activating and deactivating platinum anticancer complexes will be investigated, especially the effect of coordinated ligands (e.g. chelated diamines, halides) on the redox recognition of Pt(II) anticancer agents by disulphides and of Pt(IV) by thiols in peptides and proteins. The recognition of nucleotides and single- and double-stranded oligonucleotides by glutathione Pt macrochelates with unprecedented structures will be studied. Introduction of sulphur into the DNA backbone to provide rapid base-specific targeting of Pt (antisense/antigene strategies) will be explored. This project will allow participation in the EC COST Action D8.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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