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Combinatorial biosynthesis of lipopeptides: the function of the multienzyme system required for CDA biosynthesis
Reference
B12126
Principal Investigator / Supervisor
Professor Jason Micklefield
Co-Investigators /
Co-Supervisors
Professor Colin Smith
Institution
The University of Manchester
Department
Chemistry
Funding type
Research
Value (£)
192,320
Status
Completed
Type
Research Grant
Start date
10/04/2000
End date
10/04/2003
Duration
36 months
Abstract
The discovery of new improved antibiotics remains a major global concern. Recently we have identified and cloned a region of the Streptomyces coelicolor genome that encodes the enzymes required for the production of the Calcium-Dependent Antibiotic CDA, a complex cyclic lipopeptide. By a combined biochemical and chemical approach we will: 1) Elucidate the biosynthetic origins of CDA; 2) Determine the function of the non-ribosomal peptide synthetases and other enzymes required for CDA biosynthesis; 3) Establish a set of rules for engineering the biosynthesis of novel lipopeptides in the model actinomycete host.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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