Award details

The synthesis and pharmacology of subtype- selective ligands for neuronal nicotinic receptors

Reference	B12081
Principal Investigator / Supervisor	Professor Timothy Gallagher
Co-Investigators / Co-Supervisors	Ms Sue Wonnacott
Institution	University of Bristol
Department	Chemistry
Funding type	Research
Value (£)	154,669
Status	Completed
Type	Research Grant
Start date	01/01/2000
End date	01/01/2003
Duration	36 months

Abstract

This collaborative study, based on UB-165, a novel, enantiospecific subtype- selective nicotinic agonist, aims to define individual pharmacophores for neuronal nicotinic receptor (nAChR) subtypes, and to use the ligands to characterise native nAChR. A series of structural analogues of UB-165, as well as new classes of ligands, will be generated by efficient chemical synthesis. All ligands will be characterised pharmacologically at defined nAChR subtypes, and used to distinguish presynaptic subtypes in the brain. These results will direct ligand design, generating informative structure-activity relationships and the evolution of new, more critical pharmacophore models that will be significant for rational drug design targeted at these sites. (Joint with award B11785.)

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

B11785 The synthesis and pharmacology of subtype- selective ligands for neuronal nicotinic receptors

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