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Metalloprotein spectroscopy and structural biology of microbial and plant proteins

Reference	B11958
Principal Investigator / Supervisor	Professor Andrew Thomson
Co-Investigators / Co-Supervisors	Professor Colin Kleanthous, Professor Geoffrey Robert Moore, Professor David Richardson
Institution	University of East Anglia
Department	Chemistry
Funding type	Research
Value (£)	912,407
Status	Completed
Type	Research Grant
Start date	01/10/1999
End date	01/10/2003
Duration	48 months

Abstract

An interdisciplinary study applying advanced spectroscopic and structural methods to elucidate the functions of proteins especially those containing transition metal ions. Analysis of catalytic sites in enzymes involved in the bacterial metabolism of oxygen, nitrogen and sulphur to understand substrate specificity and catalytic reactivity in families of metalloproteins. Development and application of MCD and EPR spectroscopy to solve electronic structures of metallo-sites with emphasis on heme-, multi-haem, Fe-S, copper thiolate and molydopterin proteins. Mechanism of transcription by bacterial Ferric Uptake Regulator, Fur, by oxidative stress in Streptomyces, and by plant Myb proteins. Applications of NMR spectroscopy and Biophysical methods to structure determination ad characterisation of proteins.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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