BBSRC Portfolio Analyser
Award details
Structural basis for regulation of the complement cascade by complement receptor type 1
Reference
B09851
Principal Investigator / Supervisor
Professor Paul Barlow
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Sch of Chemistry
Funding type
Research
Value (£)
156,974
Status
Completed
Type
Research Grant
Start date
11/01/1999
End date
11/01/2002
Duration
36 months
Abstract
Complement receptor type 1 (CR1) is a multi-domain inhibitor of complement activation that has major therapeutic potential. The three-dimensional structure of a key, three-module fragment of CR1 which binds C3b will be determined using NMR. The flexibility, dynamics and thermodynamic properties of this fragment will be characterised by NMR and other physical techniques. The results will be used to explain a large body of existing mutagenesis data and to design new mutagenesis experiments. The results will also have implications for understanding of other multi- module proteins. The atomic details of ligand recognition emerging from this and parallel structural studies of complement regulators will be utilised to engineer novel complement inhibitors.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search