Award details

Structural basis for regulation of the complement cascade by complement receptor type 1

ReferenceB09851
Principal Investigator / Supervisor Professor Paul Barlow
Co-Investigators /
Co-Supervisors
Institution University of Edinburgh
DepartmentSch of Chemistry
Funding typeResearch
Value (£) 156,974
StatusCompleted
TypeResearch Grant
Start date 11/01/1999
End date 11/01/2002
Duration36 months

Abstract

Complement receptor type 1 (CR1) is a multi-domain inhibitor of complement activation that has major therapeutic potential. The three-dimensional structure of a key, three-module fragment of CR1 which binds C3b will be determined using NMR. The flexibility, dynamics and thermodynamic properties of this fragment will be characterised by NMR and other physical techniques. The results will be used to explain a large body of existing mutagenesis data and to design new mutagenesis experiments. The results will also have implications for understanding of other multi- module proteins. The atomic details of ligand recognition emerging from this and parallel structural studies of complement regulators will be utilised to engineer novel complement inhibitors.

Summary

unavailable
Committee Closed Committee - Biomolecular Sciences (BMS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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