BBSRC Portfolio Analyser
Award details
Bioactive chelate ring-opening metal complexes with novel DNA recognition properties
Reference
B08364
Principal Investigator / Supervisor
Professor Peter Sadler
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Sch of Chemistry
Funding type
Research
Value (£)
166,160
Status
Completed
Type
Research Grant
Start date
01/01/1998
End date
01/01/2001
Duration
36 months
Abstract
Novel aminophosphine complexes of Ru(II), Ru(III), Pd(II) and Pt(II) which undergo controlled chelate ring-opening reactions under conditions of biological relevance will be synthesised. The roles of the metal and dangling arm(s) in highly unusual DNA recognition reactions including supercoil unwinding, cross-linking, structural transitions, protein binding, sequence specificity and cleavage will be investigated. Their potential in antisense strategies, small molecule recognition, and as antiviral and anticancer agents will be exploited.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search