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Bioactive chelate ring-opening metal complexes with novel DNA recognition properties

Principal Investigator / Supervisor Professor Peter Sadler
Co-Investigators /
Institution University of Edinburgh
DepartmentSch of Chemistry
Funding typeResearch
Value (£) 166,160
TypeResearch Grant
Start date 01/01/1998
End date 01/01/2001
Duration36 months


Novel aminophosphine complexes of Ru(II), Ru(III), Pd(II) and Pt(II) which undergo controlled chelate ring-opening reactions under conditions of biological relevance will be synthesised. The roles of the metal and dangling arm(s) in highly unusual DNA recognition reactions including supercoil unwinding, cross-linking, structural transitions, protein binding, sequence specificity and cleavage will be investigated. Their potential in antisense strategies, small molecule recognition, and as antiviral and anticancer agents will be exploited.


Committee Closed Committee - Biomolecular Sciences (BMS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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