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Studies on oligosaccharide-protein interactions using novel heteronuclear NMR techniques at low temperature
Reference
B06636
Principal Investigator / Supervisor
Professor Steve Homans
Co-Investigators /
Co-Supervisors
Institution
University of Leeds
Department
Inst of Molecular & Cellular Biology
Funding type
Research
Value (£)
151,846
Status
Completed
Type
Research Grant
Start date
01/04/1997
End date
01/04/2000
Duration
36 months
Abstract
We propose to develop a strategy for the conformational analysis of oligosaccharides and oligosaccharide protein complexes by use of oligosaccharide ligands >95% enriched with 13C in combination with multidimensional NMR techniques at low sample temperature. The overall aims of the proposed project are as follows: (1) Application of novel multidimensional, multinuclear NMR techniques at low temperature for characterisation of structure and dynamics of 13C-enriched oligosaccharides in solution. (2) Incorporation and optimisation of these techniques in TRNOE studies on a model carbohydrate-lectin complex. (3) Application of the optimised techniques to a carbohydrate-protein interaction of topical biological interest.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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