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The mechanism of action of DNA gyrase and other topoisomerases
Reference
B05792
Principal Investigator / Supervisor
Professor Anthony Maxwell
Co-Investigators /
Co-Supervisors
Institution
University of Leicester
Department
Biochemistry
Funding type
Research
Value (£)
142,581
Status
Completed
Type
Research Grant
Start date
01/10/1996
End date
01/06/2000
Duration
44 months
Abstract
DNA topoisomerases play fundamental roles in the control of DNA higher-order structure within the cell. One of the best understood topoisomerases is DNA gyrase, the bacterial enzyme which introduces supercoils into DNA. The mechanism of action of DNA gyrase, and other topoisomerases, involves the passage of a segment of DNA through a DNA break held open by the enzyme. The aim of this proposal is to use a range of techniques, including cross- linking, site-directed mutagenesis and biophysical methods, to probe this mechanism, with particular emphasis on the strand-passage reaction.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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