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Chemical synthesis and structure/function of cell surface receptors for measles virus and Epstein-Barr
Reference
B02166
Principal Investigator / Supervisor
Professor Paul Barlow
Co-Investigators /
Co-Supervisors
Professor Robert Ramage
Institution
University of Edinburgh
Department
Sch of Chemistry
Funding type
Research
Value (£)
127,150
Status
Completed
Type
Research Grant
Start date
08/08/1995
End date
31/12/1998
Duration
40 months
Abstract
Overall aim is to combine new techniques in chemical synthesis and NMR to study relationships between peptide sequence, structure, dynamics and function. We aim to: synthesise 60-residue C-modules from viral receptors with correct folding and di-sulphides; develop techniques for covalently linking pairs of C-modules to give biologically active portions of the receptor; use NMR to determine structure and dynamics of synthetic single and double modules; study complex with synthetic viral peptides; integrate this with functional studies in collaborating lab.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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