Award details

Efficient hydroxylation catalysts based upon P450 enzymes derived from actinomycetes

Reference	ABC11432
Principal Investigator / Supervisor	Professor Nicholas Turner
Co-Investigators / Co-Supervisors	Professor Sabine Flitsch
Institution	University of Edinburgh
Department	Sch of Chemistry
Funding type	Research
Value (£)	235,854
Status	Completed
Type	Research Grant
Start date	01/12/1999
End date	01/12/2002
Duration	36 months

Abstract

The aim of this project is to develop efficient and high yielding biocatalysts for the hydroxylation of a range of organic substrates in a predictive manner. These catalysts will be based on P450 enzymes present in Actinomycetes. The strategy to be employed involves high-level expression of genes, evaluation and selection of cloning host, determination of the selectivity exhibited by expressed cell free hydroxylases, development of whole- cell systems that are capable of carrying out efficient hydroxylation reactions, development of protocols for fermentation of organisms and for carrying out whole cell biotransformations based on scale-down studies and the application of these biocatalysts to organic substrates of current interest. (Joint grant with 31/ABC11433)

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	LINK: Applied Biocatalysis (ABC) [1993-1999]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

ABC11433 Efficient hydroxylation catalysts based upon P450 enzymes derived from actinomycetes

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