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Can full-length Marek's disease virus (MDV) genome be constructed as an infectious bacterial artificial chromosome?
Reference
9810735
Principal Investigator / Supervisor
Professor Venugopal Nair
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Div of Immunology Compton
Funding type
Research
Value (£)
72,122
Status
Completed
Type
Research Grant
Start date
22/03/1999
End date
22/09/2000
Duration
18 months
Abstract
Marek's Disease (MD) is a naturally occurring neoplastic disease of poultry caused be a highly oncogenic herpesvirus. Conventional mutational approaches of MDV genome were difficult because of several reasons. A novel strategy for cloning the MDV genome in a single step as an infectious bacterial artificial chromosome in E. coli is proposed. The advantages of this method include the use of a stable infectious clone of the MDV capable of generating virus stocks of uniform characteristics and the ability to manipulate the whole genome as a single entity in E. coli independent of the biological fitness of the mutant virus.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1998 (ROPA1998) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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