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Toxicity testing using novel slow-release biosensor systems
Reference
9810708
Principal Investigator / Supervisor
Professor Ken Killham
Co-Investigators /
Co-Supervisors
Emeritus Professor Malcolm Cresser
,
Professor Lesley Glover
Institution
University of Aberdeen
Department
Plant and Soil Science
Funding type
Research
Value (£)
95,522
Status
Completed
Type
Research Grant
Start date
01/01/1999
End date
01/01/2001
Duration
24 months
Abstract
Bioluminescence-based toxicity testing using naturally luminescent and lux-marked bacteria is now well proven. Application of this technology on-line offers automated, remote toxicity testing for environmental monitoring and protection. Widespread adoption, however is hampered by the lack of an effective biosensor supply system that avoids the problems of cell resuscitation and carousel-type dispensing. This proposal aims to assess the potential of a novel cell delivery system for both lux- modified prokaryotic and eukaryotic biosensors, to overcome these constraints. The kinetics of release of biosensors incorporated into carboxylate glasses, and gelatin/collagen-based formulations will be investigated to optimise their application for on-line toxicity testing.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1998 (ROPA1998) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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