Award details

Use of surface plasmon resonance to study kinetics of molecular interactions

Reference	X04764
Principal Investigator / Supervisor	Professor Christopher Thomas
Co-Investigators / Co-Supervisors	Professor J Heath, Professor Ian Trayer
Institution	University of Birmingham
Department	Sch of Biosciences
Funding type	Research
Value (£)	150,000
Status	Completed
Type	Research Grant
Start date	01/04/1995
End date	01/04/1998
Duration	36 months

Abstract

Full understanding of biological systems depends not only on knowing the structure of the molecules and the equilibrium constant for their molecular interactions. It also requires knowledge of rates of formation and dissociation of the complexes. In this proposal, surface plasmon resonance in the Pharmacia BIACore 2000 will be applied to a number of well characterised systems to analyse the structural elements which determine the kinetics of protein-protein, protein-ligand, protein-nucleic acid and nucleic acid-nucleic acid interactions. This information is important for many areas including biological control, molecular recognition, design of bioactive compounds of industrial and pharmaceutical importance, biological catalysis and biosensor technology and the proposed programme of work covers projects with microbes, plants and animals.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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